Cheap flights from Detroit to San Francisco from C$ 215

The cheapest month to fly to San Francisco from Detroit is in July. Flight prices, which tend to average around C$ 463, are often lower during this time because this is during the off-season. The month of May is another great option to travel to San Francisco, with average flight prices from Detroit averaging around C$ 532.

The cheapest day to depart from Detroit to San Francisco is on a Wednesday. Travellers who choose to depart for San Francisco on a Wednesday will often find tickets for as low as C$ 573. On the other hand, Tuesday is the most expensive day to depart from Detroit because it is more convenient for both business and leisure travellers. As a result, prices tend to be around C$ 1,367.

Flying to San Francisco from Detroit in the morning is the least expensive time of day to depart. momondo users have found prices as low as C$ 708 when looking at flights departing in the morning. In contrast, the most expensive time of day to depart to San Francisco is in the evening when prices are around C$ 1,228.

Fly from Detroit Metropolitan Wayne County to San Francisco for the best Detroit - San Francisco flight prices

You are more likely to see cheaper flights to San Francisco from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around C$ 601 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Detroit for as low as C$ 434 on momondo.

There are 2 cabin classes available to choose from on Detroit to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 53% on your flight if you consider stops on a Detroit to San Francisco flight.

As of April 2026, prices for Detroit to San Francisco flights are approximately 121% more expensive when compared to flights at the same time last year.

Southwest, United Airlines, and Alaska Airlines are the most popular carriers operating from Detroit to San Francisco

Delta, United Airlines and Frontier are the top three most popular airlines that fly to San Francisco from Detroit according to our data. Delta is the first choice among our users, with 38% of people opting to fly with this airline when travelling to San Francisco. Keep in mind that there are 5 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

Chicago (ORD) was the most common stop: 50% of momondo users choosing one-stop flights on this route connected there.

Flights via Minneapolis (MSP) offer the lowest average round-trip price of C$ 430.

Flights connecting via Minneapolis (MSP) have the shortest average one-way travel time: 6h 48m.

Minneapolis (MSP) has the shortest average layover time for this route: 0h 49m.

The number of flights available between Detroit and San Francisco is 10 per day as of April 2026. The most frequent departure time is 7:00a.m., with 63% of daily flights leaving at noon.

74 flights are operational weekly from Detroit to San Francisco as of April 2026. The most popular departure day for this route is Mon, with 15% of flights per week taking off on this day.