Travelling from most locations, it is best to book your flight to Panama City during the month of September for the best deal, although there are other times of the year which offer great deals as well.
In general, most flyers find the cheapest time to book a flight to Panama City is about 60 days prior.
In general, booking your departure to Panama City for a Thursday represents the best deal on airfare. Try to avoid a Saturday departure to stay away from the highest prices.
Typically, cheap prices to Panama City are most often found for evening flights. Cheap prices are less likely for afternoon flights.